Tumor microenvironment: a mechanical force link
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چکیده
منابع مشابه
Microenvironment and Immunology Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Crosstalk between tumor and stromal cells in the tumormicroenvironment alter its properties in ways that facilitate the invasive behavior of tumor cells. Here, we demonstrate that cancer-associated fibroblasts (CAF) increase the stiffness of the extracellular matrix (ECM) and promote anisotropic fiber orientation, two mechanical signals generated through a Snail1/RhoA/aSMA– dependent mechanism ...
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ژورنال
عنوان ژورنال: Science China Life Sciences
سال: 2015
ISSN: 1674-7305,1869-1889
DOI: 10.1007/s11427-014-4796-x